PREP

Across TCGA patient cohorts, PREP RNA expression is significantly associated with the protein abundance of many other proteins, with 10,496 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PREP-associated proteins across cancer lineages are SYNCRIP, CDC40, and AFDN. Each is linked with PREP in more than 5 cancer types. Because this analysis shows association rather than direction, both PREP-to-partner and partner-to-PREP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PREP versus SYNCRIP in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PREP→partner) and Y-score (partner→PREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNCRIP →	+0.367	+0.395	<.001	<.001	3	5
GBM	CDC40 →	+0.311	+0.437	<.001	<.001	3	5
BRCA	AFDN →	+0.309	+0.308	.006	.009	2	6
BRCA	VTA1 →	+0.373	+0.443	<.001	.001	2	5
BRCA	PM20D2 →	+1.165	+0.625	<.001	<.001	3	4
BRCA	FOXO3 →	+0.324	+0.475	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,496 associations by consensus.

PREP vs SYNCRIP — GBM

Explore this scatter interactively →