PREP

Across TCGA patient cohorts, PREP protein abundance is significantly associated with the RNA expression of many other genes, with 7,713 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PREP-associated genes across cancer lineages are SEC63, UFL1, and CDK19. Each is linked with PREP in more than 5 cancer types. Because this analysis shows association rather than direction, both PREP-to-partner and partner-to-PREP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PREP versus SEC63 in OV, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREP→partner) and Y-score (partner→PREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEC63 →	+0.493	+0.364	<.001	<.001	3	6
GBM	UFL1 →	+0.614	+0.325	<.001	<.001	3	6
GBM	CDK19 →	+0.662	+0.283	<.001	<.001	3	6
OV	HACE1 →	+0.793	+0.300	<.001	<.001	3	6
OV	CD164 →	+0.718	+0.394	<.001	<.001	3	5
BRCA	SMPD2 →	+0.623	+0.314	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,713 associations by consensus.

PREP vs SEC63 — OV

Explore this scatter interactively →