PREP

Across TCGA patient cohorts, PREP mutation is significantly associated with the RNA expression of many other genes, with 3,137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREP-associated genes across cancer lineages are BUB3, MED8, and PPP2R2D. Each is linked with PREP in more than 2 cancer types. Because this analysis shows association rather than direction, both PREP-to-partner and partner-to-PREP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by PREP-low versus PREP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREP→partner) and Y-score (partner→PREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.416	+2.297	<.001	.004	3	3
UCEC	MED8 →	+0.243	+2.475	.008	<.001	3	3
SKCM	PPP2R2D →	+0.443	+3.195	.002	.009	3	3
UCEC	ZBTB8OS →	+0.315	+1.868	<.001	<.001	3	3
UCEC	ORC1 →	+0.597	+1.836	.001	.001	3	3
UCEC	ALKBH5 →	+0.412	+3.828	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,137 associations by consensus.

BUB3 by PREP expression — UCEC

Explore this box plot interactively →