PREP

Across TCGA patient cohorts, PREP mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREP-associated genes across cancer lineages are C-Raf, Caspase-7-cleavedD198, and Caspase-8. Each is linked with PREP in more than 2 cancer types. Because this analysis shows association rather than direction, both PREP-to-partner and partner-to-PREP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PREP-low versus PREP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREP→partner) and Y-score (partner→PREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.180	+2.222	<.001	.010	3	3
COAD	Caspase-7-cleavedD198 →	+1.598	+3.016	<.001	.018	3	2
UCEC	Caspase-8 →	-0.246	-2.295	.006	.005	3	2
UCEC	4E-BP1 →	+0.231	+1.584	.017	.019	3	2
UCEC	14-3-3_beta →	-0.103	-2.432	.004	.018	3	1
UCEC	EGFR_pY1068 →	-0.269	-2.415	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

C-Raf by PREP expression — UCEC

Explore this box plot interactively →