PREP

Across TCGA cell cohorts, PREP mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PREP-associated genes across cancer lineages are OTOL1, KRTAP1-1, and TGM7. Each is linked with PREP in more than 1 cancer types. Because this analysis shows association rather than direction, both PREP-to-partner and partner-to-PREP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOL1 grouped by PREP-low versus PREP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREP→partner) and Y-score (partner→PREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OTOL1 →	+0.012	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP1-1 →	+0.068	+5.209	<.001	.005	3	1
URINARY_TRACT	TGM7 →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	OR13D1 →	+0.026	+4.217	<.001	.005	3	1
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
LARGE_INTESTINE	PROP1 →	+0.020	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

OTOL1 by PREP expression — BLOOD_Lymphoma

Explore this box plot interactively →