PRDX6

Across TCGA patient cohorts, PRDX6 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDX6-associated genes across cancer lineages are p62 Lck ligand, Myosin-IIa_pS1943, and Shc_pY317. Each is linked with PRDX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDX6-to-partner and partner-to-PRDX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PRDX6-low versus PRDX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX6→partner) and Y-score (partner→PRDX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.362	+3.321	.034	.010	3	2
UCEC	Myosin-IIa_pS1943 →	+0.229	+2.183	.034	.035	3	1
UCEC	Shc_pY317 →	-0.253	-3.000	.001	.036	3	1
UCEC	Caspase-8 →	-0.342	-3.321	.009	.010	2	1
UCEC	CDK1 →	+0.164	+3.000	.038	.036	2	1
UCEC	p21 →	+0.275	+3.321	.006	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by PRDX6 expression — UCEC

Explore this box plot interactively →