Across TCGA pan-cancer cohorts, PRDX6-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRDX6-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PRDX6-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PRDX6-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

UCS, LIHC, and UCEC are the cancer types where PRDX6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.676	0.147	<.001	122	view →
LIHC	OS	Median	All	0.701	0.857	<.001	92	view →
UCEC	DFS	Median	All	0.502	0.773	<.001	86	view →
KIRP	DFS	Tertile	IV	0.042	0.624	.002	59	view →
ACC	DFS	Quartile	All	0.277	0.781	<.001	56	view →
KICH	OS	Quartile	All	0.617	1.000	.001	36	view →
SKCM	DFS	Tertile	III,IV	0.389	0.142	.003	32	view →
KIRC	DFS	Tertile	IV	0.175	0.409	.006	30	view →
LUAD	OS	Quartile	II,III,IV	0.746	0.389	.004	25	view →
GBM	OS	Median	All	0.206	0.323	.002	23	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	15	view →
MESO	OS	Tertile	III,IV	0.316	0.476	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: PRDX6-AS1 tumor-vs-normal RNA expression · all PRDX6-AS1 data types