PRDX5

Across TCGA cell cohorts, PRDX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,252 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PRDX5-associated GO terms across cancer lineages are Mitochondrial electron transport, succinate to ubiquinone, Resolution of DNA recombination intermediates, and Regulation of protein K48-linked deubiquitination. Each is linked with PRDX5 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRDX5-to-partner and partner-to-PRDX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial electron transport, succinate to ubiquinone grouped by PRDX5-low versus PRDX5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX5→partner) and Y-score (partner→PRDX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Mitochondrial electron transport, succinate to ubiquinone →	+0.069	+0.680	<.001	<.001	3	9
SOFT_TISSUE	Resolution of DNA recombination intermediates →	-0.172	-0.687	<.001	<.001	3	9
OESOPHAGUS	Regulation of protein K48-linked deubiquitination →	+0.085	+1.092	<.001	.004	3	9
SOFT_TISSUE	Centriole assembly →	-0.067	-0.536	.001	.008	3	9
LARGE_INTESTINE	Sister chromatid cohesion →	-0.069	-0.743	<.001	<.001	3	8
SOFT_TISSUE	Constitutive heterochromatin formation →	-0.098	-0.682	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,252 associations by consensus.

Mitochondrial electron transport, succinate to ubiquinone by PRDX5 expression — SKIN

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