PRDX4

Across TCGA patient cohorts, PRDX4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDX4-associated genes across cancer lineages are Caspase-7-cleavedD198, Fibronectin, and GSK3-a-b. Each is linked with PRDX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDX4-to-partner and partner-to-PRDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRDX4-low versus PRDX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX4→partner) and Y-score (partner→PRDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.585	+3.019	.034	.019	3	2
UCEC	Fibronectin →	-0.310	-3.700	.044	.001	3	1
UCEC	GSK3-a-b →	-0.159	-2.584	.011	.011	3	1
UCEC	p90 RSK_pT359_S363 →	+0.229	+3.009	.015	.019	3	1
UCEC	SLC1A5 →	-0.469	-2.314	.028	.035	3	1
UCEC	Tuberin_pT1462 →	+0.273	+2.331	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by PRDX4 expression — UCEC

Explore this box plot interactively →