PRDX4

Across TCGA cell cohorts, PRDX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,417 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PRDX4-associated GO terms across cancer lineages are Cotranslational protein targeting to membrane, Carbohydrate derivative catabolic process, and Collagen biosynthetic process. Each is linked with PRDX4 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRDX4-to-partner and partner-to-PRDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cotranslational protein targeting to membrane grouped by PRDX4-low versus PRDX4-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX4→partner) and Y-score (partner→PRDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Cotranslational protein targeting to membrane →	+0.082	+0.805	<.001	.002	3	9
SOFT_TISSUE	Carbohydrate derivative catabolic process →	+0.078	+1.103	<.001	<.001	3	8
STOMACH	Collagen biosynthetic process →	+0.208	+1.459	<.001	<.001	3	8
SKIN	Protein N-linked glycosylation →	+0.054	+0.665	.001	.004	3	8
KIDNEY	miRNA metabolic process →	-0.078	-0.751	.001	.008	2	9
CNS	Amino sugar metabolic process →	+0.061	+0.673	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,417 associations by consensus.

Cotranslational protein targeting to membrane by PRDX4 expression — BLOOD_Lymphoma

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