PRDX3

Across TCGA patient cohorts, PRDX3 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDX3-associated genes across cancer lineages are DSCR4-IT1, RNA5SP436, and BUD31P1. Each is linked with PRDX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDX3-to-partner and partner-to-PRDX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR4-IT1 grouped by PRDX3-low versus PRDX3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX3→partner) and Y-score (partner→PRDX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DSCR4-IT1 →	+0.956	+4.855	<.001	.002	3	2
UCEC	RNA5SP436 →	+0.629	+3.715	<.001	.002	3	2
BRCA	BUD31P1 →	+0.439	+7.731	<.001	.009	3	1
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	1
UCEC	GLE1 →	+0.571	+3.210	.004	.009	3	1
UCEC	NUSAP1 →	+1.047	+3.202	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

DSCR4-IT1 by PRDX3 expression — LUAD

Explore this box plot interactively →