PRDX3

Across TCGA cell cohorts, PRDX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,859 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDX3-associated GO terms across cancer lineages are Mitochondrial DNA replication, DNA replication initiation, and Lagging strand elongation. Each is linked with PRDX3 in more than 13 cancer types. Because this analysis shows association rather than direction, both PRDX3-to-partner and partner-to-PRDX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial DNA replication grouped by PRDX3-low versus PRDX3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX3→partner) and Y-score (partner→PRDX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitochondrial DNA replication →	+0.131	+1.237	<.001	.001	3	14
BONE	DNA replication initiation →	+0.198	+0.569	.002	.002	3	14
BLOOD_Myeloma	Lagging strand elongation →	+0.153	+0.978	<.001	<.001	3	14
KIDNEY	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.133	+0.572	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.175	+1.575	<.001	<.001	3	13
BONE	Quinone biosynthetic process →	+0.109	+0.631	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,859 associations by consensus.

Mitochondrial DNA replication by PRDX3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →