PRDX2

Across TCGA patient cohorts, PRDX2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDX2-associated genes across cancer lineages are p62 Lck ligand, PDK1_pS241, and Shc_pY317. Each is linked with PRDX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDX2-to-partner and partner-to-PRDX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PRDX2-low versus PRDX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX2→partner) and Y-score (partner→PRDX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.374	+3.321	.028	.010	3	1
UCEC	PDK1_pS241 →	+0.253	+2.183	.004	.035	3	1
UCEC	Shc_pY317 →	-0.226	-3.000	.004	.036	3	1
UCEC	Caspase-8 →	-0.309	-3.000	.019	.036	3	1
UCEC	Myosin-IIa →	+0.308	+3.329	.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by PRDX2 expression — UCEC

Explore this box plot interactively →