PRDM9

Across TCGA patient cohorts, PRDM9 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,468 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PRDM9-associated GO terms across cancer lineages are Sister chromatid segregation, Negative regulation of DNA metabolic process, and Protein localization to chromosome, centromeric region. Each is linked with PRDM9 in more than 14 cancer types. Because this analysis shows association rather than direction, both PRDM9-to-partner and partner-to-PRDM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid segregation grouped by PRDM9-low versus PRDM9-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM9→partner) and Y-score (partner→PRDM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Sister chromatid segregation →	+0.076	+0.129	<.001	<.001	3	15
STAD	Negative regulation of DNA metabolic process →	+0.054	+0.107	<.001	<.001	3	14
STAD	Protein localization to chromosome, centromeric region →	+0.060	+0.131	<.001	<.001	3	14
STAD	Mitotic spindle assembly →	+0.071	+0.116	<.001	<.001	3	14
ESCA	Telomerase RNA localization →	+0.094	+0.273	<.001	<.001	3	14
STAD	Pseudouridine synthesis →	+0.059	+0.122	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,468 associations by consensus.

Sister chromatid segregation by PRDM9 expression — STAD

Explore this box plot interactively →