PRDM9

Across TCGA patient cohorts, PRDM9 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM9-associated genes across cancer lineages are PCNA, JNK_pT183_Y185, and RBM15. Each is linked with PRDM9 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRDM9-to-partner and partner-to-PRDM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PRDM9-low versus PRDM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM9→partner) and Y-score (partner→PRDM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.230	+2.285	<.001	<.001	3	4
UCEC	JNK_pT183_Y185 →	-0.152	-2.058	<.001	<.001	3	3
LUSC	RBM15 →	+0.204	+1.079	.049	.038	3	3
BLCA	ASNS →	+0.399	+3.321	.028	.010	3	3
LUAD	S6 →	+0.268	+2.392	<.001	<.001	3	3
COAD	4E-BP1_pS65 →	+0.220	+2.012	.026	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

PCNA by PRDM9 expression — UCEC

Explore this box plot interactively →