PRDM9

Across TCGA cell cohorts, PRDM9 mutation is significantly associated with the RNA expression of many other genes, with 1,378 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM9-associated genes across cancer lineages are NLN, ORC1, and SMYD1. Each is linked with PRDM9 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM9-to-partner and partner-to-PRDM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLN grouped by PRDM9-low versus PRDM9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM9→partner) and Y-score (partner→PRDM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NLN →	+0.585	+2.850	.003	<.001	3	3
LARGE_INTESTINE	ORC1 →	+0.675	+3.169	.002	.009	3	3
BREAST	SMYD1 →	+0.213	+3.115	<.001	.008	3	2
OVARY	TSHB →	+0.115	+3.990	<.001	.003	3	2
BREAST	TM4SF5 →	+0.193	+3.632	.004	.009	3	2
SKIN	KRTAP16-1 →	+0.014	+2.560	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,378 associations by consensus.

NLN by PRDM9 expression — LARGE_INTESTINE

Explore this box plot interactively →