PRDM7

Across TCGA patient cohorts, PRDM7 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,022 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PRDM7-associated GO terms across cancer lineages are Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Autophagosome maturation, and ERAD pathway. Each is linked with PRDM7 in more than 19 cancer types. Because this analysis shows association rather than direction, both PRDM7-to-partner and partner-to-PRDM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by PRDM7-low versus PRDM7-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM7→partner) and Y-score (partner→PRDM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.090	+0.116	<.001	<.001	3	20
STAD	Autophagosome maturation →	+0.065	+0.070	<.001	<.001	3	20
STAD	ERAD pathway →	+0.063	+0.074	<.001	<.001	3	20
STAD	Endosomal transport →	+0.061	+0.070	<.001	<.001	3	19
STAD	Negative regulation of cellular catabolic process →	+0.054	+0.066	<.001	<.001	3	19
STAD	Negative regulation of TOR signaling →	+0.059	+0.071	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,022 associations by consensus.

Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by PRDM7 expression — ESCA

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