PRDM7

Across TCGA patient cohorts, PRDM7 mutation is significantly associated with the RNA expression of many other genes, with 3,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM7-associated genes across cancer lineages are RPS29P25, NDUFS6P1, and WRBP1. Each is linked with PRDM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM7-to-partner and partner-to-PRDM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P25 grouped by PRDM7-low versus PRDM7-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM7→partner) and Y-score (partner→PRDM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RPS29P25 →	+0.194	+7.962	<.001	.007	3	2
LUAD	NDUFS6P1 →	+0.217	+5.197	<.001	.003	3	2
SKCM	WRBP1 →	+0.171	+4.104	<.001	.002	3	2
SKCM	SNORD116-25 →	+0.289	+3.869	<.001	.004	3	2
LUSC	UBE2V1P8 →	+0.118	+4.412	.001	.006	3	2
BLCA	LINC00709 →	+1.446	+3.602	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,364 associations by consensus.

RPS29P25 by PRDM7 expression — THCA

Explore this box plot interactively →