PRDM7

Across TCGA patient cohorts, PRDM7 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM7-associated genes across cancer lineages are FASN, TFRC, and C-Raf. Each is linked with PRDM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM7-to-partner and partner-to-PRDM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PRDM7-low versus PRDM7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM7→partner) and Y-score (partner→PRDM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.396	+2.222	.017	.011	3	2
UCEC	TFRC →	+0.448	+2.222	.047	.011	3	2
UCEC	C-Raf →	+0.218	+2.222	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.280	-2.321	.008	.033	3	1
UCEC	eIF4E →	+0.196	+3.183	.028	.009	3	1
UCEC	ER-alpha_pS118 →	-0.327	-3.169	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FASN by PRDM7 expression — UCEC

Explore this box plot interactively →