PRDM7

Across TCGA cell cohorts, PRDM7 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRDM7-associated genes across cancer lineages are GPR101, OR52A5, and OR52E2. Each is linked with PRDM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM7-to-partner and partner-to-PRDM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by PRDM7-low versus PRDM7-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM7→partner) and Y-score (partner→PRDM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR101 →	+0.070	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR52A5 →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52E2 →	+0.237	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.073	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52E6 →	+0.168	+4.887	<.001	.009	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GPR101 by PRDM7 expression — OESOPHAGUS

Explore this box plot interactively →