PRDM5

Across TCGA patient cohorts, PRDM5 mutation is significantly associated with the RNA expression of many other genes, with 3,656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM5-associated genes across cancer lineages are RNU6-92P, SMIM10, and SRA1. Each is linked with PRDM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM5-to-partner and partner-to-PRDM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-92P grouped by PRDM5-low versus PRDM5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM5→partner) and Y-score (partner→PRDM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-92P →	+0.330	+5.763	<.001	.001	3	3
UCEC	SMIM10 →	-0.545	-1.645	<.001	<.001	3	3
UCEC	SRA1 →	+0.226	+1.592	.002	.002	3	3
UCEC	TIMM21 →	+0.389	+1.852	<.001	<.001	3	3
UCEC	UBE2S →	+0.468	+1.189	.005	.009	3	3
UCEC	SCO1 →	+0.461	+1.885	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,656 associations by consensus.

RNU6-92P by PRDM5 expression — HNSC

Explore this box plot interactively →