PRDM5

Across TCGA patient cohorts, PRDM5 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM5-associated genes across cancer lineages are eEF2, eIF4E, and FOXO3a_pS318_S321. Each is linked with PRDM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM5-to-partner and partner-to-PRDM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PRDM5-low versus PRDM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM5→partner) and Y-score (partner→PRDM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.257	+2.115	.015	.016	3	2
COAD	eIF4E →	+0.219	+2.820	.017	.035	3	2
UCEC	FOXO3a_pS318_S321 →	-0.114	-1.864	.002	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.124	-1.584	.013	.017	3	2
UCEC	NF-kB-p65_pS536 →	-0.267	-1.700	.049	.040	3	2
UCEC	PDCD4 →	-0.467	-1.584	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eEF2 by PRDM5 expression — UCEC

Explore this box plot interactively →