PRDM5

Across TCGA cell cohorts, PRDM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,502 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRDM5-associated GO terms across cancer lineages are Chromosome segregation, Mitotic sister chromatid segregation, and Positive regulation of chromosome organization. Each is linked with PRDM5 in more than 11 cancer types. Because this analysis shows association rather than direction, both PRDM5-to-partner and partner-to-PRDM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosome segregation grouped by PRDM5-low versus PRDM5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM5→partner) and Y-score (partner→PRDM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Chromosome segregation →	+0.093	+0.906	.001	<.001	3	11
BLOOD_Lymphoma	Mitotic sister chromatid segregation →	+0.082	+0.503	<.001	.001	2	12
STOMACH	Positive regulation of chromosome organization →	+0.076	+1.849	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Spindle organization →	+0.065	+1.016	.003	<.001	3	10
CNS	Regulation of cell cycle G1/S phase transition →	+0.062	+1.003	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.118	+0.957	.006	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,502 associations by consensus.

Chromosome segregation by PRDM5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →