PRDM5

Across TCGA cell cohorts, PRDM5 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible PRDM5-associated genes across cancer lineages are SHISAL2B, SPHKAP, and PDILT. Each is linked with PRDM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM5-to-partner and partner-to-PRDM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHISAL2B grouped by PRDM5-low versus PRDM5-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM5→partner) and Y-score (partner→PRDM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SHISAL2B →	+0.169	+4.011	<.001	.009	3	1
PANCREAS	SPHKAP →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	PDILT →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	SLC13A1 →	+0.015	+4.614	<.001	.004	3	1
URINARY_TRACT	NOBOX →	+0.016	+4.044	<.001	.001	3	1
URINARY_TRACT	NPHS2 →	+0.150	+4.044	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SHISAL2B by PRDM5 expression — PANCREAS

Explore this box plot interactively →