PRDM4

Across TCGA cell cohorts, PRDM4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRDM4-associated genes across cancer lineages are CIB4, KRTAP5-11, and KRTAP10-12. Each is linked with PRDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM4-to-partner and partner-to-PRDM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CIB4 grouped by PRDM4-low versus PRDM4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM4→partner) and Y-score (partner→PRDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CIB4 →	+0.056	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP5-11 →	+0.033	+4.807	<.001	.006	3	1
CNS	KRTAP10-12 →	+0.046	+5.754	<.001	.002	3	1
CNS	TAS2R39 →	+0.044	+4.981	<.001	.008	3	1
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	MOS →	+0.018	+5.209	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CIB4 by PRDM4 expression — BLOOD_Myeloma

Explore this box plot interactively →