PRDM2

Across TCGA patient cohorts, PRDM2 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM2-associated genes across cancer lineages are GAPDH, FASN, and PKC-delta_pS664. Each is linked with PRDM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRDM2-to-partner and partner-to-PRDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PRDM2-low versus PRDM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM2→partner) and Y-score (partner→PRDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.615	+3.012	.007	.018	3	4
STAD	FASN →	+0.399	+2.823	.041	.034	2	4
STAD	PKC-delta_pS664 →	-0.142	-2.984	.025	.034	3	3
LUSC	4E-BP1_pT70 →	+0.215	+2.821	.031	.035	3	3
UCEC	ACC1 →	+0.291	+1.722	.003	<.001	3	3
UCEC	INPP4B →	-0.235	-2.247	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

GAPDH by PRDM2 expression — COAD

Explore this box plot interactively →