PRDM2

Across TCGA cell cohorts, PRDM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,710 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRDM2-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Epigenetic regulation of gene expression. Each is linked with PRDM2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PRDM2-to-partner and partner-to-PRDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by PRDM2-low versus PRDM2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM2→partner) and Y-score (partner→PRDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of DNA-templated transcription initiation →	+0.136	+0.850	<.001	<.001	3	17
OESOPHAGUS	Negative regulation of transcription initiation by RNA polymerase II →	+0.136	+0.850	<.001	<.001	3	17
BONE	Epigenetic regulation of gene expression →	+0.088	+0.984	<.001	<.001	3	17
STOMACH	Pre-miRNA processing →	+0.101	+0.679	<.001	<.001	3	16
BONE	RISC complex assembly →	+0.146	+1.314	<.001	<.001	3	16
BONE	Positive regulation of DNA metabolic process →	+0.099	+1.035	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,710 associations by consensus.

Negative regulation of DNA-templated transcription initiation by PRDM2 expression — OESOPHAGUS

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