PRDM2

Across TCGA cell cohorts, PRDM2 mutation is significantly associated with the RNA expression of many other genes, with 932 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM2-associated genes across cancer lineages are L2HGDH, SIGLECL1, and RIDA. Each is linked with PRDM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM2-to-partner and partner-to-PRDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L2HGDH grouped by PRDM2-low versus PRDM2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM2→partner) and Y-score (partner→PRDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	L2HGDH →	+0.505	+3.364	.005	.002	3	3
BREAST	SIGLECL1 →	+0.013	+3.781	<.001	.009	3	2
STOMACH	RIDA →	-0.709	-3.099	.003	.008	3	2
STOMACH	AURKB →	+0.801	+3.240	.008	.003	3	2
LARGE_INTESTINE	CBY1 →	+0.620	+2.722	<.001	<.001	3	2
LARGE_INTESTINE	TXN2 →	+0.463	+2.244	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 932 associations by consensus.

L2HGDH by PRDM2 expression — SKIN

Explore this box plot interactively →