PRDM16-DT

Across TCGA patient cohorts, PRDM16-DT RNA expression is significantly associated with the protein abundance of many other proteins, with 17,216 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRDM16-DT-associated proteins across cancer lineages are SORBS2, CACNA2D2, and DDAH1. Each is linked with PRDM16-DT in more than 5 cancer types. Because this analysis shows association rather than direction, both PRDM16-DT-to-partner and partner-to-PRDM16-DT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRDM16-DT versus SORBS2 in HNSC, with a Pearson correlation of 0.22.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM16-DT→partner) and Y-score (partner→PRDM16-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SORBS2 →	+0.441	+0.388	.003	.005	3	6
GBM	CACNA2D2 →	+0.685	+0.515	<.001	<.001	3	5
LUAD	DDAH1 →	+0.477	+0.740	<.001	<.001	3	5
PDAC	RPS19 →	-0.295	-0.505	.001	.003	3	5
LSCC	SORBS2_S259 →	+0.605	+0.261	<.001	.002	3	5
HNSC	PRKAR2B →	+0.648	+0.230	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,216 associations by consensus.

PRDM16-DT vs SORBS2 — HNSC

Explore this scatter interactively →