PRDM15

Across TCGA patient cohorts, PRDM15 mutation is significantly associated with the RNA expression of many other genes, with 4,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM15-associated genes across cancer lineages are UBE2L3, C4orf46, and C16orf95. Each is linked with PRDM15 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRDM15-to-partner and partner-to-PRDM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2L3 grouped by PRDM15-low versus PRDM15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM15→partner) and Y-score (partner→PRDM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2L3 →	+0.285	+2.811	<.001	<.001	3	4
UCEC	C4orf46 →	+0.596	+3.555	<.001	<.001	3	4
SKCM	C16orf95 →	+0.339	+2.594	.002	.006	3	4
UCEC	MPHOSPH6 →	+0.505	+4.413	<.001	<.001	3	4
UCEC	MMS22L →	+0.368	+1.606	<.001	<.001	3	4
UCEC	RASSF1 →	+0.293	+2.130	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,949 associations by consensus.

UBE2L3 by PRDM15 expression — UCEC

Explore this box plot interactively →