PRDM15

Across TCGA patient cohorts, PRDM15 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM15-associated genes across cancer lineages are eEF2, STAT3_pY705, and Cyclin-B1. Each is linked with PRDM15 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM15-to-partner and partner-to-PRDM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PRDM15-low versus PRDM15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM15→partner) and Y-score (partner→PRDM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.309	+2.906	.004	.001	3	3
UCEC	STAT3_pY705 →	-0.316	-1.504	<.001	.014	3	3
UCEC	Cyclin-B1 →	+0.556	+1.847	.001	.007	3	2
UCEC	p62 Lck ligand →	+0.288	+1.754	.003	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.618	+1.412	<.001	.010	3	2
UCEC	4E-BP1 →	+0.363	+1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by PRDM15 expression — UCEC

Explore this box plot interactively →