PRDM15

Across TCGA cell cohorts, PRDM15 mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM15-associated genes across cancer lineages are TSPAN16, SLC66A2, and DUSP2. Each is linked with PRDM15 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM15-to-partner and partner-to-PRDM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN16 grouped by PRDM15-low versus PRDM15-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM15→partner) and Y-score (partner→PRDM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TSPAN16 →	+0.044	+3.080	<.001	.004	3	2
LARGE_INTESTINE	SLC66A2 →	+0.822	+3.321	.002	.003	3	2
LARGE_INTESTINE	DUSP2 →	+1.291	+2.628	<.001	.002	3	2
LARGE_INTESTINE	B3GNT4 →	+0.762	+3.459	<.001	.001	3	2
LARGE_INTESTINE	CRELD2 →	+0.673	+3.169	.002	.009	3	2
LARGE_INTESTINE	MTFP1 →	+0.602	+3.743	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

TSPAN16 by PRDM15 expression — BREAST

Explore this box plot interactively →