PRDM10

Across TCGA patient cohorts, PRDM10 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM10-associated genes across cancer lineages are RAD51, MEK1_p_S217_S221, and eIF4E. Each is linked with PRDM10 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRDM10-to-partner and partner-to-PRDM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by PRDM10-low versus PRDM10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM10→partner) and Y-score (partner→PRDM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAD51 →	+0.173	+2.095	.001	.003	3	4
LUSC	MEK1_p_S217_S221 →	+0.180	+2.816	.029	.036	3	3
UCEC	eIF4E →	+0.161	+1.494	.006	.001	3	3
UCEC	TIGAR →	+0.104	+1.280	.013	.049	3	3
UCEC	ATM →	-0.591	-1.678	<.001	<.001	3	3
COAD	Chk1 →	+0.248	+1.330	.001	.045	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

RAD51 by PRDM10 expression — COAD

Explore this box plot interactively →