PRDM10

Across TCGA cell cohorts, PRDM10 mutation is significantly associated with the RNA expression of many other genes, with 655 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM10-associated genes across cancer lineages are TRIM2, CNR2, and ASB17. Each is linked with PRDM10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM10-to-partner and partner-to-PRDM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM2 grouped by PRDM10-low versus PRDM10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM10→partner) and Y-score (partner→PRDM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRIM2 →	+1.283	+3.364	<.001	.002	3	2
LARGE_INTESTINE	CNR2 →	+0.101	+2.918	.002	.001	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	GPR101 →	+0.016	+4.990	<.001	.001	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
LARGE_INTESTINE	GTPBP1 →	+0.832	+3.451	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 655 associations by consensus.

TRIM2 by PRDM10 expression — LARGE_INTESTINE

Explore this box plot interactively →