PRDM1

Across TCGA patient cohorts, PRDM1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, PDCD4, and ERK2. Each is linked with PRDM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM1-to-partner and partner-to-PRDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by PRDM1-low versus PRDM1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM1→partner) and Y-score (partner→PRDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.585	+1.807	.002	.022	3	3
SKCM	PDCD4 →	-0.401	-2.584	.003	.009	3	3
SKCM	ERK2 →	+0.186	+2.239	.010	.004	3	2
UCEC	Gab2 →	+0.248	+1.514	.012	.014	3	2
UCEC	ACC1 →	+0.234	+1.598	.020	.019	3	2
UCEC	PDK1_pS241 →	+0.120	+1.523	.011	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Acetyl-a-Tubulin-Lys40 by PRDM1 expression — SKCM

Explore this box plot interactively →