PRDM1

Across TCGA cell cohorts, PRDM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,868 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRDM1-associated GO terms across cancer lineages are Intracellular receptor signaling pathway, Cytoplasmic pattern recognition receptor signaling pathway, and Asparaginyl-tRNA aminoacylation. Each is linked with PRDM1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PRDM1-to-partner and partner-to-PRDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular receptor signaling pathway grouped by PRDM1-low versus PRDM1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM1→partner) and Y-score (partner→PRDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Intracellular receptor signaling pathway →	+0.057	+0.482	<.001	.006	3	11
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.084	+2.615	<.001	<.001	3	11
BLOOD_Myeloma	Asparaginyl-tRNA aminoacylation →	-0.137	-1.226	.003	.001	2	11
LARGE_INTESTINE	Positive regulation of Wnt signaling pathway →	+0.046	+0.948	<.001	<.001	3	10
SOFT_TISSUE	Cellular response to environmental stimulus →	+0.046	+1.011	<.001	<.001	3	10
SOFT_TISSUE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.318	+1.054	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,868 associations by consensus.

Intracellular receptor signaling pathway by PRDM1 expression — OVARY

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