PRDM1

Across TCGA cell cohorts, PRDM1 mutation is significantly associated with the RNA expression of many other genes, with 360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM1-associated genes across cancer lineages are ANKRD45, SEMG1, and PTH. Each is linked with PRDM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM1-to-partner and partner-to-PRDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD45 grouped by PRDM1-low versus PRDM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM1→partner) and Y-score (partner→PRDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD45 →	+0.227	+2.451	<.001	.009	3	2
BLOOD_Lymphoma	SEMG1 →	+0.010	+3.169	.001	.008	3	1
BLOOD_Lymphoma	PTH →	+0.009	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	OR52K2 →	+0.009	+3.794	<.001	.001	3	1
BLOOD_Lymphoma	HTR3D →	+0.008	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	MAGEE2 →	+0.004	+3.794	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 360 associations by consensus.

ANKRD45 by PRDM1 expression — LARGE_INTESTINE

Explore this box plot interactively →