PRCP

Across TCGA patient cohorts, PRCP mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRCP-associated genes across cancer lineages are PDCD4, PKC-a, and EGFR_pY1068. Each is linked with PRCP in more than 1 cancer types. Because this analysis shows association rather than direction, both PRCP-to-partner and partner-to-PRCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PRCP-low versus PRCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRCP→partner) and Y-score (partner→PRCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.598	-2.990	.015	.036	3	1
UCEC	PKC-a →	+0.428	+2.820	.043	.035	3	1
UCEC	EGFR_pY1068 →	-0.288	-3.321	.028	.010	1	1
UCEC	ATM →	-0.635	-3.321	.007	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PDCD4 by PRCP expression — UCEC

Explore this box plot interactively →