PRCC

Across TCGA patient cohorts, PRCC protein abundance is significantly associated with the RNA expression of many other genes, with 16,325 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRCC-associated genes across cancer lineages are UTP25, MRPL24, and UCHL5. Each is linked with PRCC in more than 8 cancer types. Because this analysis shows association rather than direction, both PRCC-to-partner and partner-to-PRCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRCC versus UTP25 in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRCC→partner) and Y-score (partner→PRCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UTP25 →	+0.612	+0.306	<.001	<.001	3	9
UCEC	MRPL24 →	+1.484	+0.290	<.001	<.001	3	9
LSCC	UCHL5 →	+0.558	+0.295	<.001	<.001	3	8
UCEC	DAP3 →	+1.082	+0.342	<.001	<.001	3	8
UCEC	UCK2 →	+0.861	+0.221	<.001	<.001	3	8
HNSC	MRPL9 →	+0.710	+0.246	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,325 associations by consensus.

PRCC vs UTP25 — BRCA

Explore this scatter interactively →