PRCC

Across TCGA patient cohorts, PRCC mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRCC-associated genes across cancer lineages are Class-switched memory B-cells, Erythrocytes, and Endothelial cells. Each is linked with PRCC in more than 1 cancer types. Because this analysis shows association rather than direction, both PRCC-to-partner and partner-to-PRCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Class-switched memory B-cells grouped by PRCC-low versus PRCC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRCC→partner) and Y-score (partner→PRCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Class-switched memory B-cells →	+0.102	+3.086	.004	.027	3	2
UCEC	Erythrocytes →	+0.033	+3.071	.005	.017	3	2
UCEC	Endothelial cells →	-0.041	-2.991	.026	.036	2	1
UCEC	lymphatic Endothelial cells →	-0.025	-2.405	.030	.021	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Class-switched memory B-cells by PRCC expression — BLCA

Explore this box plot interactively →