PRCC

Across TCGA cell cohorts, PRCC mutation is significantly associated with the mutation status of many other genes, with 3,102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRCC-associated genes across cancer lineages are CDH6, UBE3A, and PTPRA. Each is linked with PRCC in more than 2 cancer types. Because this analysis shows association rather than direction, both PRCC-to-partner and partner-to-PRCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH6 grouped by PRCC-low versus PRCC-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRCC→partner) and Y-score (partner→PRCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CDH6 →	+5.502	+5.502	.003	.003	1	3
BLOOD_Lymphoma	UBE3A →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	PTPRA →	+5.169	+5.832	<.001	<.001	1	3
BLOOD_Lymphoma	SLC18A1 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	CDK13 →	+2.847	+4.327	.006	.006	1	3
CNS	MIDEAS →	+5.614	+5.044	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,102 associations by consensus.

CDH6 by PRCC expression — SOFT_TISSUE

Explore this box plot interactively →