PRCC

Across TCGA cell cohorts, PRCC mutation is significantly associated with the drug of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRCC-associated genes across cancer lineages are Nutlin-3a (-), AGI-6780, and 50869. Each is linked with PRCC in more than 1 cancer types. Because this analysis shows association rather than direction, both PRCC-to-partner and partner-to-PRCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by PRCC-low versus PRCC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRCC→partner) and Y-score (partner→PRCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+1.066	+2.646	.002	.047	3	1
LARGE_INTESTINE	AGI-6780 →	+0.401	+2.646	.038	.047	3	1
LARGE_INTESTINE	50869 →	+0.492	+2.710	.019	.027	3	1
LARGE_INTESTINE	150412 →	+0.394	+2.777	.018	.038	3	1
LARGE_INTESTINE	630600 →	+0.699	+2.649	.024	.046	3	1
LARGE_INTESTINE	LMP744 →	+0.673	+2.649	.047	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Nutlin-3a (-) by PRCC expression — LARGE_INTESTINE

Explore this box plot interactively →