Across TCGA pan-cancer cohorts, PRC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRC1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PRC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where PRC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.466	0.923	.024	6	view →
LSCC	DFS	Quartile	All	0.866	0.611	.021	3	view →
HNSC	OS	Median	III,IV	0.449	1.000	.023	2	view →
LUAD	DFS	Quartile	All	0.421	0.723	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PRC1 tumor-vs-normal RNA expression · all PRC1 data types