Across TCGA patient cohorts, PRC1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRC1-associated genes across cancer lineages are INPP4B, P-Cadherin, and Caspase-7-cleavedD198. Each is linked with PRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRC1-to-partner and partner-to-PRC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRC1→partner) and Y-score (partner→PRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.273	-2.222	.017	.009	3	2
UCEC	P-Cadherin →	-0.164	-2.115	.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.576	+2.242	.005	.005	3	2
UCEC	EGFR_pY1068 →	-0.307	-3.000	<.001	<.001	3	1
UCEC	EGFR →	-0.200	-2.558	<.001	.010	3	1
UCEC	A-Raf_pS299 →	-0.168	-2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

PRC1 survival (RNA) · tumor vs normal (RNA) · all PRC1 data types