PRB3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PRB3 mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRB3-associated genes across cancer lineages are RNA5SP423, RN7SL255P, and RN7SL369P. Each is linked with PRB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRB3-to-partner and partner-to-PRB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB3→partner) and Y-score (partner→PRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUSCRNA5SP423 →+0.561+5.733<.001<.00133
SKCMRN7SL255P →+0.335+2.190<.001<.00132
SKCMRN7SL369P →+0.130+2.071<.001.00232
SKCMPPIAL4F →+0.037+1.722.006.00832
LUADUBTFL2 →+0.618+5.315<.001.00332
SARCRNA5SP194 →+0.599+5.111<.001.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

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