Across TCGA patient cohorts, PRB3 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRB3-associated genes across cancer lineages are Astrocytes, Endothelial cells, and Macrophages. Each is linked with PRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB3-to-partner and partner-to-PRB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB3→partner) and Y-score (partner→PRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Astrocytes →	+0.123	+2.994	.001	.044	3	1
SKCM	Endothelial cells →	-0.033	-2.974	.028	.035	3	1
SKCM	Macrophages →	-0.023	-1.540	.046	.037	3	1
SKCM	pro B-cells →	-0.070	-2.470	.039	.002	3	1
SKCM	lymphatic Endothelial cells →	-0.018	-2.478	.033	.014	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

PRB3 survival (RNA) · tumor vs normal (RNA) · all PRB3 data types