PRB1

Across TCGA pan-cancer cohorts, PRB1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PRB1 data layer compared with 16 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PRB1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRB1 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

LGG and LUSC are the cancer types where PRB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.172	0.845	<.001	9	view →
LUSC	DFS	Median	All	0.856	0.382	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PRB1–LGG (DFS)

Open the LGG breakdown →