Across TCGA patient cohorts, PRB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,093 significant associations in total. LGG shows the largest number of these associations.

The most reproducible PRB1-associated GO terms across cancer lineages are Regulation of proteolysis involved in protein catabolic process, Positive regulation of proteolysis involved in protein catabolic process, and Negative regulation of mitotic cell cycle. Each is linked with PRB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PRB1-to-partner and partner-to-PRB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB1→partner) and Y-score (partner→PRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	Regulation of proteolysis involved in protein catabolic process →	+0.042	+0.045	<.001	<.001	3	7
MESO	Positive regulation of proteolysis involved in protein catabolic process →	+0.040	+0.043	<.001	.001	3	7
UCEC	Negative regulation of mitotic cell cycle →	+0.045	+0.037	<.001	.003	3	7
MESO	Positive regulation of intracellular transport →	+0.033	+0.026	<.001	.004	3	7
MESO	Regulation of intracellular protein transport →	+0.028	+0.034	<.001	<.001	2	8
MESO	Regulation of establishment of T cell polarity →	+0.059	+0.031	.001	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,093 associations by consensus.

Exploration

PRB1 survival (RNA) · tumor vs normal (RNA) · all PRB1 data types