PRB1

Across TCGA patient cohorts, PRB1 mutation is significantly associated with the RNA expression of many other genes, with 830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRB1-associated genes across cancer lineages are SMPD4, PGBD4P8, and APOBEC3AP1. Each is linked with PRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB1-to-partner and partner-to-PRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMPD4 grouped by PRB1-low versus PRB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB1→partner) and Y-score (partner→PRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMPD4 →	+0.601	+3.332	.004	.005	3	2
HNSC	PGBD4P8 →	+0.076	+4.578	<.001	.008	3	2
UCEC	APOBEC3AP1 →	+0.218	+2.994	<.001	.003	3	2
SKCM	IDH3B →	+0.336	+2.019	.008	.005	3	2
SKCM	SMG9 →	+0.329	+3.397	.008	.004	3	2
SKCM	FBXL15 →	+0.426	+2.535	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 830 associations by consensus.

SMPD4 by PRB1 expression — UCEC

Explore this box plot interactively →