PRB1

Across TCGA patient cohorts, PRB1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRB1-associated genes across cancer lineages are naive B-cells, CD4+ T-cells, and CD4+ Tcm. Each is linked with PRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB1-to-partner and partner-to-PRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, naive B-cells grouped by PRB1-low versus PRB1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB1→partner) and Y-score (partner→PRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	naive B-cells →	+0.038	+3.556	<.001	.032	3	2
BRCA	CD4+ T-cells →	+0.085	+6.133	<.001	.027	3	1
BRCA	CD4+ Tcm →	+0.018	+6.725	.001	.018	3	1
LUSC	Hepatocytes →	+0.020	+2.510	<.001	.029	3	1
UCEC	Macrophages M2 →	+0.013	+2.287	.017	.030	3	1
UCEC	Epithelial cells →	-0.103	-3.161	.006	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

naive B-cells by PRB1 expression — HNSC

Explore this box plot interactively →